Studies have shown that animal assisted therapy can be a beneficial part of multimodal management of many various symptoms, ranging from depression and anxiety to acute and chronic pain. Animal-assisted interventions (AAI) have been known to improve discomfort, stress, anxiety, and overall well-being in children and adults. In addition to subjective reports from patients, biomarkers have been used to investigate a positive response to AAI. All of the following objective measures have been utilized indicating a positive response to AAI except: