Society for Pediatric Pain Medicine
Better Care for Children in Pain

{“questions”:{“ua2ox”:{“id”:”ua2ox”,”mediaType”:”image”,”answerType”:”text”,”imageCredit”:””,”image”:””,”imageId”:””,”video”:””,”imagePlaceholder”:””,”imagePlaceholderId”:””,”title”:”\r\nMembrane stabilizers are commonly used to treat both acute and chronic pain in children and adolescents. Which of the following is the MOST likely mechanism of gabapentin?”,”desc”:””,”hint”:””,”answers”:{“orgb6”:{“id”:”orgb6″,”image”:””,”imageId”:””,”title”:”A. Selective inhibition of GABA_{B<\/sub> receptors containing the GABAB1a<\/sub> and GABAB2<\/sub> subunits”},”pwhg6″:{“id”:”pwhg6″,”image”:””,”imageId”:””,”title”:”B. Selective inhibition on voltage-gated calcium channels containing the \u03b12\u03b4-1 subunit”,”isCorrect”:”1″},”gq3nj”:{“id”:”gq3nj”,”image”:””,”imageId”:””,”title”:”C. Selective inhibition on voltage-gated sodium channels containing the \u03b12\u03b4-1 subunit”},”5nxh8″:{“id”:”5nxh8″,”image”:””,”imageId”:””,”title”:”D. Selective inhibition on voltage-gated potassium channels containing the \u03b12\u03b4-1 subunit”}}}},”results”:{“azuqm”:{“id”:”azuqm”,”title”:””,”image”:”https:\/\/pedspainmedicine.org\/wp-content\/uploads\/2021\/08\/SPPM-QOM-August-2021.jpg”,”imageId”:”1791″,”min”:”0″,”max”:”1″,”desc”:”Correct Answer: B. Selective inhibition on voltage-gated calcium channels containing the \u03b12\u03b4-1 subunit \r\n\r\nAlthough early proposed mechanisms of gabapentin were interaction by activation of the GABAB<\/sub> receptors containing the GABAB1a<\/sub> and GABAB2<\/sub> subunits, thereby enhancing NMDA current or inhibiting AMPA-receptor-mediated transmission to the spinal cord, more recent studies have instead favored selective inhibition at the \u03b12\u03b4-1 subunit of spinal N-type Ca (2+) channels.\r\n\r\nReferences: \r\n1.\tChen J, Li L, Chen SR, et al. The \u03b12\u03b4-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions. Cell Rep<\/em>. 2018;22(9):2307-2321. doi:10.1016\/j.celrep.2018.02.021 \r\n\r\n2.\tCheng JK, Chiou LC. Mechanisms of the antinociceptive action of gabapentin. J Pharmacol Sci. 2006;100(5):471-86. doi: 10.1254\/jphs.cr0050020. Epub 2006 Feb 11. PMID: 16474201. \r\n\r\n3.\tLi G, Li P. (2020, Summer) The use of membrane stabilizers in acute and chronic pain. SPPM Newsletter<\/em>. Retrieved from https:\/\/pedspainmedicine.org\/wp-\r\ncontent\/uploads\/newsletters\/2020\/summer\/nonopioid\/Membrane%20Stabilizers%20.html \r\n\r\n4.\tSills GJ, Rogawski MA. Mechanisms of action of currently used antiseizure drugs. Neuropharmacology. 2020 May 15;168:107966. doi: 10.1016\/j.neuropharm.2020.107966. Epub 2020 Jan 14. PMID: 32120063. \r\n”,”redirect_url”:””}}}}