Society for Pediatric Pain Medicine
Better Care for Children in Pain

The Society for Pediatric Pain Medicine (SPPM) aims to advance the quality of anesthesia care and the alleviation of pain-related conditions in children.

Society for Pediatric
Pain Medicine

Better Care for Children in Pain

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Question of the Month – August 2021

Membrane stabilizers are commonly used to treat both acute and chronic pain in children and adolescents. Which of the following is the MOST likely mechanism of gabapentin?

Correct! Wrong!

Question of the Month - August 2021

Correct Answer: B. Selective inhibition on voltage-gated calcium channels containing the α2δ-1 subunit


Although early proposed mechanisms of gabapentin were interaction by activation of the GABAB receptors containing the GABAB1a and GABAB2 subunits, thereby enhancing NMDA current or inhibiting AMPA-receptor-mediated transmission to the spinal cord, more recent studies have instead favored selective inhibition at the α2δ-1 subunit of spinal N-type Ca (2+) channels.


References:


1. Chen J, Li L, Chen SR, et al. The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions. Cell Rep. 2018;22(9):2307-2321. doi:10.1016/j.celrep.2018.02.021


2. Cheng JK, Chiou LC. Mechanisms of the antinociceptive action of gabapentin. J Pharmacol Sci. 2006;100(5):471-86. doi: 10.1254/jphs.cr0050020. Epub 2006 Feb 11. PMID: 16474201.


3. Li G, Li P. (2020, Summer) The use of membrane stabilizers in acute and chronic pain. SPPM Newsletter. Retrieved from https://pedspainmedicine.org/wp- content/uploads/newsletters/2020/summer/nonopioid/Membrane%20Stabilizers%20.html


4. Sills GJ, Rogawski MA. Mechanisms of action of currently used antiseizure drugs. Neuropharmacology. 2020 May 15;168:107966. doi: 10.1016/j.neuropharm.2020.107966. Epub 2020 Jan 14. PMID: 32120063.


Upcoming Meeting Information

SPPM 11th Annual Meeting
April 11, 2024
Anaheim Marriott
Anaheim, CA

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Meeting Registration – early registration rates through March 22, 2024
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