Membrane stabilizers are commonly used to treat both acute and chronic pain in children and adolescents. Which of the following is the MOST likely mechanism of gabapentin?
Although early proposed mechanisms of gabapentin were interaction by activation of the GABAB receptors containing the GABAB1a and GABAB2 subunits, thereby enhancing NMDA current or inhibiting AMPA-receptor-mediated transmission to the spinal cord, more recent studies have instead favored selective inhibition at the α2δ-1 subunit of spinal N-type Ca (2+) channels.
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3. Li G, Li P. (2020, Summer) The use of membrane stabilizers in acute and chronic pain. SPPM Newsletter. Retrieved from https://pedspainmedicine.org/wp- content/uploads/newsletters/2020/summer/nonopioid/Membrane%20Stabilizers%20.html
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